![]() ![]() The eco-conscious approach demonstrated here represents a paradigm shift in biofabrication, and will accelerate the translation of scalable biomaterials and biomimetic scaffolds for tissue engineering and regenerative medicine. 62.87 ± 2.49% alpha helical content, n = 3, p < 0.05) and recapitulating native ECM mechanics in the fabrication of biopolymer-based meshes (16.57 ± 3.92% ductility, 33.38 ± 30.26 MPa elastic modulus, 1.30 ± 0.19 MPa yield strength, and 2.13 ± 0.36 MPa ultimate tensile strength, n = 10). Most importantly, green electrospinning proves advantageous for biofabrication, rendering a greater protection of growth factors during fiber formation (72.30 ± 1.94 vs. Interestingly, material properties of green synthetic fibers are more biomimetic than those of traditionally electrospun fibers, doubling in ductility (91.86 ± 35.65 vs. Resulting ‘green’ fibers and composites are comparable to traditional meshes in terms of composition, chemistry, architecture, mechanical properties, and biocompatibility. poly-α-hydroxyesters, collagen), polymer blends, polymer-ceramic composites, and growth factor delivery systems. By tuning electrospinning parameters, such as needle-plate distance and flow rate, we updated the fabrication of widely utilized biomedical polymers (e.g. kg/L) and supports a stable electrospinning jet under routine fabrication conditions. Food and Drug Administration Q3C Class 3), and have identified acetic acid as a green solvent that exhibits low ecological impact (global warming potential (GWP) = 1.40 CO 2 eq. Applying sustainability principles to biomaterial production, we have developed a ‘green electrospinning’ process by systematically testing biologically benign solvents (U.S. In the biomaterials industry, electrospinning is a ubiquitous fabrication method for producing nano- to micro-scale fibrous meshes that resemble native tissues, but this process traditionally utilizes solvents that are environmentally hazardous and pose a significant barrier to industrial scale-up and clinical translation. Green manufacturing has emerged across industries, propelled by a growing awareness of the negative environmental and health impacts associated with traditional practices. Helen H Lu: Conceptualization Data curation Funding acquisition Methodology Project administration Resources Software: Supervision Validation Writing-original draft Writing-review & editing. Theanne N Schiros: Conceptualization Data curation Investigation Methodology Resources Software Supervision Validation Visualization Writing-review & editing. Elisa C Fang: Formal analysis Investigation Validation Writing-review & editing. Romare M Antrobus: Formal analysis Investigation Validation Writing-review & editing. Sang Won Lee: Formal analysis Investigation Methodology Validation Writing-review & editing. Hannah R Childs: Formal analysis Investigation Methodology Validation Writing-review & editing. Zhengxiang Gong: Data curation Formal analysis Investigation Writing-review & editing. Philip A P Brudnicki: Conceptualization Data curation Formal analysis Investigation Methodology Validation Writing-review & editing. Credit authorship contribution statementChristopher Z Mosher: Conceptualization Data curation Formal analysis Funding acquisition Investigation Methodology Validation Visualization Writing-original draft Writing-review & editing. ![]()
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